This may have been brought up in the past but I think it would be helpful (especially during Global Events) if there was a toggle in your preferences that allows you to attack Champion class creatures with the number keys. This of course would be off by default.
Currently, during a Global Event that has Champion Class creatures (potion Globals) if you want to attack the champion creatures, you either have to do a LOT of clicking or you can switch to the classic map to use your keyboard. Most don't know about the classic map workaround and even if you do you probably agree that that map is much slower.
This is really a pain during these events but adding a toggle to attack these creatures with the keyboard can help even beyond the Globals. Some players may even want this functionality always enabled.
I'm not sure if you would want to allow this for SE and Titan creatures but I'm sure many would like this ability.