Being able to drag party frames to a more sensible location would really help out prophets. Clicking on each individual party portrait is not optimal as it is, it just makes it that much worse that it's in the top right hand corner of my screen. It seems like the coding is already there in the game as we can drag around trade windows, inventory and a bunch of other stuff, so why not let us have a little bit more UI customization. Wouldn't have to stop with party frames but mini map, action bars, chat window, all that kind of stuff. Then just give everyone a "Lock" option like you have currently for putting moves onto the action bar.
Showing de-buffs under the players party portrait would also be extremely helpful for Prophets as currently the only way you could pro actively use Serenity would be clicking each individual player. This is just not practical.