Well, it's very hard to find a problem when we don't know where to look, so lets run some real examples.
*I'll always use the base of 50K for all status, just to make easier to work*
And I don't know how each buff is layered, which active first than others, so I'll be working with only the 50.000 base.
Cur Ruby Box:
Constituition 525 - 52,5% Increase on Defense.
50.000 becomes 76250.
Smashing Hammer 525 - 26,25% Increase on Damage per set equipped.
50.000 becomes 105.000 (26,25x4 since we will be using 4 sets)
Keen Edge 525 - 52,5% Increase on Attack for each set equipped.
50.000 becomes 165.000 (52,5x4 since we wll be using 4 sets)
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That's just a small example, and with that we can easily see that it is IMPOSSIBLE to match those numbers without using another Global/Epic Potion yourself, there is simple no way lvl 175/192 buffs can beat a player using those big potions if they're the same level you're, with equivalent gear.
To beat someone using those big potions the only way for hitting/killing them is by using Fist Fight and trying the odds of getting an activation.
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Now we need to analyze what that means for the game mechanics, and how to abuse it.
1st - GvG.
You can have a very competitive and well dressed team on your GvG Guild, but if a Guild start a Conflict with yours, and they are using those pots, there is NO WAY to protect your Guild, simply because you're not able to use your potion on your guildmates, and if they're offline they can't drink it for themselves, that makes completely useless any try to cast buffs or anything, you just wait for them to finish the attacks and try to find a gap where they go offline and the buffs runs out.
For me that kills the idea of Guild Conflicts entirely.
2nd - Bounty Board.
A player can hit everyone on they level range hourly, and receive multiple bounties on their head, and no one will be able to clear those bounties if the person countinues to use those potions.
3rd - Ladder.
Any player can use those potions and never lose a hit (attacking or defending), considering the enemy is not using the same potions.
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For those things kills PvP, and make the players with more ways to access those potions way too ahead of those who can't, that means rich players who buys more Epic Potion and those with more stamina banks to get Top 100 on Globals and receive extra Chests.
For me PvP should not have buffs over lvl192.
Once you start any PvP combat the buff level should become 192 (or less if the buff you're using is not 192 or higher), that would not change the level of your buff during PvE, you'll not lose your SH480 if you hit a player, only for that combat.
That would give the same fighting chance for everyone, and create a very more friendly PvP game, which will make knowledge and pratice a very important roll on the PvP scenario, and will not change the power level of the big potions during PvE/Levelling.