For a time, I was having a bit of trouble with my wrists. i switched to using my left hand for using the mouse. No more pain. Takes probably 40 hours to get used to it, then it's second nature, just like the right hand.
Personally, I think one-clicking a resource would feel more boring...though I do sympathize with those with pain.
They should give new players one of the good sacks with 10 slots, so they see how helpful those are. I was very frustrated with storage when i first started, until I figured out how to use the sacks. Now (with 10 sacks) I could gather for hours and hours without needing to empty.
The baskets help to sell some items quickly. You can just sell the whole basket and the basket becomes empty and you can retrieve it. I was nervous when I tried it the first time thinking I might lose my basket.